Abstract：The severe combat wound and trauma may lead to shock, infection, sepsis and other complications and may further results in multiple organ dysfunction (MODS), with a high casualty rate and treatment difficulties. The inflammatory reaction is a common intermediate link in the occurrence of the abovementioned complications. Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs that mainly inhibit cyclooxygenase activity and thus reduce prostaglandin synthesis, with anti-inflammatory, analgesic, antipyretic and antiplatelet effects. An appropriate amount of NSAIDs plays an active role in treatment of severe combat wound and trauma. The NSAIDs can delay or even prevent the occurrence of complications of severe combat wound and trauma and improve the prognosis of the wounded, especially when used in combination with antibiotics. The authors review the research status, clinical application and research progress of NSAIDs in treatment of severe combat wound and trauma, so as to provide new strategies for preventing or delaying the occurrence of complications of severe combat wound and trauma and improving the prognosis of the wounded.
