Objective  To study the clinical efficacy of vacuum sealing drainage (VSD) plus topical oxygen therapy for traumatic wounds.   Methods  A retrospective casecontrol study was conducted to analyze the clinical data of 60 patients with traumatic wounds admitted to Daping Hospital of Army Medical University from July 2016 to June 2019, including 34 males and 26 females, aged 22-72 years［(42.2±12.8)years］. There were 48 patients with wound sites in lower extremities, 9 in upper extremities, 3 in back. The area of the wounds was 30-156 cm²［(76.9±25.1)cm²］. A total of 20 patients were treated with regular dressing (Group A), 20 patients were treated with VSD plus irrigation of saline (Group B), and 20 patients were treated with vacuum sealing drainage plus irrigation of saline loaded with oxygen (Group C). Bacteria clearance rate, granulation tissue coverage rate and partial pressure of oxygen of the exudate in wounds were compared among the three groups. Foam dry rate and blockage rate of drainage tube were compared between Group B and Group C. Wound healing time, dressing change time and hospitalization day were compared among the three groups.   Results  Bacterial clearance rate of wounds in Group B ［(78.3±7.0)%］ and Group C ［(85.3±9.7)%］ was higher than that in Group A ［(58.5±11.1)%］ (both P＜0.05), while Group C was higher than that in Group B (P＜0.05). Granulation tissue coverage rate of wounds in Group B ［(71.5±9.9)%］ and Group C ［(86.0±9.2)%］ was higher than that in Group A ［(49.1±14.7)%］ (both P＜0.05), while Group C was higher than that in Group B (P＜0.05). Partial pressure of oxygen of the exudate in wounds in Group B ［(49.5±10.1)%］ and Group C ［(80.9±12.1)%］ was higher than that in Group A［(49.4±11.2) %］ (both P＜0.05),  while Group C was higher than that in Group B (P＜0.05). The foam dry rate ［9.5 (5.0, 13.8)%］ and drainage tube blockage rate ［0.6 (0, 1.7)%］ in Group C showed no significant difference with that ［9.0 (5.0, 10.0)%, 0.6 (0, 1.2)%］ in Group B (P＞0.05). Wounds healing time in Groups A, B, C were (36.5±4.8)days,  (25.9±3.9)days,  (25.5±4.2)days, respectively； dressing change times in Groups A, B, C were 23.0 (20.3, 27.8)times, 8.0 (6.0, 9.0)times, 7.5 (5.3, 9.0)times, respectively； hospitalization day in Groups A, B, C were 23.5 (19.0, 27.8)d, 17.0 (15.3, 19.0)d, 17.0 (16.0, 18.8)d, respectively. These outcomes in Group B and Group C showed significant differences compared to Group A (P＜0.05), while there were no significant differences between Group B and Group C (P＞0.05).   Conclusions  VSD plus topical oxygen therapy can facilitate wound healing and reduce dressing change frequency for traumatic wounds compared to traditional methods. The technique can also improve bacterial clearance rate and granulation tissue coverage rate of wounds compared to VSD plus irrigation of saline, but the difference of wounds healing time is similar.