Abstract：Post-traumatic osteoarthritis (PTOA) is a condition with symptoms of swelling of damaged joints, joint effusion, pain, and even joint hematoma caused by acute joint injury. Although studies have shown that a variety of molecular and biological mechanisms are involved in PTOA pathogenesis and disease progression, activation of acute inflammatory response after joint injury is thought to play a key role in the occurrence and development of PTOA. To some extent, the study of PTOA patients and animal models reveals the process of inflammatory mediators production, activation of inflammatory pathways, infiltration of inflammatory cells and the influence of inflammatory response on the occurrence and development of PTOA after joint injury, which is of great significance for the further development of preventive and therapeutic PTOA measures and drugs. The authors explore the progress of inflammatory mechanism of PTOA by reviewing the in vivo and in vitro research models, local inflammatory manifestations, inflammatory mediators, systemic inflammatory influencing factors, and inflammatory pathways to provide a reference for clinical prevention and treatment in PTOA.
丰瑞兵 王华松 刘曦明 汪国栋 李彦锦 姜壮 蔡贤华. 创伤性骨关节炎的炎症机制研究进展[J]. 中华创伤杂志, 2020, 36(12): 1146-1152.
Feng Ruibing, Wang Huasong, Liu Ximing, Wang Guodong, Li Yanjin, Jiang Zhuang, Cai Xianhua.. Research progress in inflammatory mechanism of post-traumatic osteoarthritis. CHINESE JOURNAL OF TRAUMA, 2020, 36(12): 1146-1152.
