The early treatments after fasciotomy of compartment syndrome mainly focused on metabolic disorder caused by ischemia-reperfusion injury,including hypokalemia,metabolic acidosis,rhabdomyolysis,and myoglobinuria.There was no evidence for conventional anticoagulation after surgery due to the risk of bleeding.Continuous negative pressure drainage was useful in reducing tissue damage caused by ischemia-reperfusion and improving tissue blood supply.In addition,hyperbaric oxygen was also effective in preventing tissue ischemia and necrosis after ischemia-reperfusion injury.In recent years,as the representative closure method of incision of fasciotomy,the "shoe lace technique" has been widely used in clinical practices,together with derived commercial products,the incidence of incision complications was effectively reduced.The author reviewed the progress in management of postoperative factors related to fasciotomy of compartment syndrome so as to provide reference for improving clinical curative effect.