Abstract：Objective To explore the changes and clinical significance of inflammatory indices of urogenic sepsis with different severity. Methods A retrospective case-control study was used to analyze the clinical data of 71 patients with urogenic sepsis admitted to 940th Hospital of PLA Joint Logistics Support Force from January 2010 to April 2018，including 34 males and 37 females, aged 39-96 years ［(63.1±18.3)years］. The patients were divided into three groups according to the clinical diagnostic criteria for septic shock and sepsis according to the 2014 edition of the Chinese Urology Surgical Guidelines for Diagnosis and Treatment: 21 cases in sepsis group ［sequential organ failure assessment (SOFA) score of 3.0 (2.0, 3.0)points］, 21 cases in severe sepsis group ［SOFA score of 9.0 (6.0, 11.0)points］, and 29 cases in septic shock group ［SOFA score of 15.0 (14.0，16.0)points］. Spearman correlation analysis was used to analyze the correlation of inflammatory indicators with SOFA, including white blood cell count, percentage of neutrophils, C-reactive protein, interleukin-6, procalcitonin, fibrinogen, D-dimer, and platelet. Multiple linear regression analysis and stepwise regression weighted analysis were performed to analyze the relation between inflammatory indicators and sepsis severity. Levels of each inflammatory indicator was detected and compared among the groups. Results ① Spearman correlation analysis: percentage of neutrophils, D-dimer, interleukin-6, procalcitonin and SOFA scores were significantly positively correlated，with the rs value of 0.738,0.712,0.31,0.795, respectively (P<0.01); platelet and SOFA scores were significantly negatively correlated, with the rsvalue of -0.661 (P<0.01). ② Multiple linear regression analysis: percentage of neutrophils, platelet, D-dimer, procalcitonin and SOFA score were significantly correlated (P<0.01)；Stepwise regression weighted analysis suggested that the model linear relationship and fit was good. ③ Inflammatory index comparison: percentage of neutrophils in sepsis group, severe sepsis group and septic shock group was 82.30 (76.25，88.45), 90.50 (86.55,93.85), 95.10 (92.05，97.95), respectively; level of platelet was 183.01 (144.50,246.50)×109/L, 149.11 (81.04,207.00)×109/L, 81.26 (50.01,93.50)×109/L, respectively; level of D-dimer was 0.98 (0.71,1.74)mg/L,3.45 (1.79,5.56)mg/L, 7.19 (4.26,11.63)mg/L, respectively; level of procalcitonin was 0.55 (0.21,1.09)ng/ml, 5.45 (3.74,11.80)ng/ml,17.68 (13.97,26.75)ng/ml, respectively. There were significant differences in above indicators among the groups (P<0.05). Conclusions The serum levels of procalcitonin, percentage of neutrophils, D-dimer and platelet are positively correlated with the severity of urogenic sepsis. While combined detection of those indicators can better predict the severity of the sepsis.
杨旭凯 谭乐明 杨成 周水英 蔡高平 张大伟 常德辉 张斌 李卫平 王养民 董永超. 不同严重程度尿源性脓毒血症患者炎性指标变化及其临床意义[J]. 中华创伤杂志, 2020, 36(6): 544-549.
Yang Xukai, Tan Leming, Yang Cheng, Zhou Shuiying, Cai Gaoping, Zhang Dawei, Chang Dehui, Li Weiping, Zhang Bin, Wang Yangmin, Dong Yongchao.. Changes and clinical significance of inflammatory indices in patients with urogenic sepsis with different severity. CHINESE JOURNAL OF TRAUMA, 2020, 36(6): 544-549.
