Consciousness disorders are common in patients with severe traumatic brain injury ( sTBI) . There are some differences in the definitions of consciousness disorders in neurophysiology, neuropathology, neuroendocrinology, psychology and philosophy, which makes the evaluation and treatment of patients with consciousness disorders more complicated. The clinical multidisciplinary collaboration can make the assessment more accurate, so as to discover the residual consciousness of patients with consciousness disorder. In terms of treatment, sTBI patients are in critical condition and develop rapidly, accompanied by different systemic injuries and dysfunction of multiple systems, leading to long duration of consciousness disturbance and many complications. Neurosurgery, critical care medicine and rehabilitation medicine have their own advantages and disadvantages, and they have different clinical treatment decisions in handling patients with consciousness disorders. Therefore, multidisciplinary participation is needed in clinical treatment. Multidisciplinary collaboration can reduce the mortality, shorten hospitalization time, reduce hospitalization costs and improve the quality of life of patients with consciousness disorder after sTBI. The author discusses the value of multidisciplinary collaboration in the treatment of patients with post-sTBI consciousness disorder, in order to provide reference for improving clinical efficacy.