Abstract：Objective To investigate the clinical effect of standard large decompressive craniotomy in treatment of intracranial hematoma induced by severe traumatic brain injury (sTBI) and its influence on neuron-specific enolase (NSE) and inflammatory cytokines. Methods A total of 168 patients with sTBI-induced intracranial hematoma were assigned to standard large decompressive craniotomy (standard group) and traditional treatment (control group), with 84 patients per group. Glasgow outcome scale (GOS) and levels of serum NSE, TNF-α, IL-6 and IL-10 were compared between the two groups after surgery. Results GOS was better in standard group than in control group after surgery (P<0.05). Standard group presented significantly lower levels of serum NSE, TNF-α and IL-6 (P<0.05), significantly higher level of IL-10 (P<0.05) and a dropped ratio of IL-6 to IL-10 after surgery. However, there was no significant change in control group. Mean survival time of the patients in standard group was (33.11±0.62) months. Two-year and three-year survival rate were significantly higher in standard group than in control group. Conclusion Standard large decompressive craniotomy cna enhance the clinical effects in patients with sTBI-induced intracranial hematoma, improve their neurologic deficits and daily living ability and decrease their body inflammatory stress level and injury.
ZHOU Chang-long,SUN Xiao-chuan,HE Xue-nong et al. Standard large decompressive craniotomy in treatment of severe traumatic brain injury[J]. CHINESE JOURNAL OF TRAUMA, 2013, 29(8): 739-742.
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