重型颅脑损伤患者血清Mg<sup>2+</sup>与免疫球蛋白的关系

doi:10.3760/cma.j.issn.1001-8050.2013.3.012

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摘要目的研究重型颅脑损伤(severe traumatic brain injury, sTBI)患者免疫球蛋白IgG、IgA、IgM与血清Mg2+浓度下降之间的关系。方法 60例sTBI患者按随机数字表法分为对照组和研究组。研究组静脉补充硫酸镁后，分别监测两组受伤后第l，3，7，14天血清Mg2+浓度及IgG、IgA、IgM含量，分析血清Mg2+浓度与各项体液免疫指标的关系。结果研究组IgG、IgM含量在3，7 d分别为（10.79±2.65）g/L和（10.21±2.54）g/L，高于对照组(P<0.05)。研究组IgM含量在3，7 d分别为（1.27±0.32）g/L和（1.31±0.25）g/L，高于对照组（P＜0.05）。两组IgA含量差异无统计学意义。Mg2+浓度与IgM、IgG含量呈正相关，与IgA含量无相关性。但两组患者14 d后的病情改善差异无统计学意义。结论 sTBI患者急性期静脉补充硫酸镁能够改善体液免疫抑制状态，但并不能改善预后。

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	苏海
	张毅
	孙晓川
	苏祖禄
	贺学农
	陈皓

关键词 ：脑损伤, 免疫球蛋白类, 镁

Abstract：Objective To investigate relationship of immunoglobulin concentrations （IgG, IgA, and IgM）and decrease of serum Mg2+ concentration in patients with severe traumatic brain injury (sTBI). Methods Sixty patients with sTBI were randomly divided into control group and study group. Intravenous injection of MgSO4 was given to study group. Levels of Mg2+ in serum and immunoglobulin (IgG, IgA, and IgM) in both groups were measured at 1, 3, 7, and 14 days after injury so as to analyze correlations of serum Mg2+ concentration with each humoral immune indices. Results IgG concentration at days 3 and 7 in study group were (10.79±2.65)g/L and (10.21±2.54)g/L respectively, higher than that in control group (P<0.05). IgM at days 3 and 7 in study group were (1.27±0.32)g/L and (1.31±0.25)g/L respectively, higher than that in control group (P<0.05). Difference of IgA level between the two groups was not significant. Level of Mg2+was positively related to levels of IgM and IgG, but not to level of IgA. Pathological amelioration at day 14 between the two groups showed insignificant difference. Conclusion Intravenous replenishment of MgSO4 for patients with sTBI at acute phase can improve humoral immunosuppressive state, but can not ameliorate prognosis.

Key words： Brain injuries Immunoglobulins Magnesium

基金资助:重庆医科大学附属永川医院基金资助项目(2010075)

通讯作者: 苏祖禄，电话：13272904772，Email：panda957@tom.com

引用本文:

苏海,张毅,孙晓川等. 重型颅脑损伤患者血清Mg²⁺与免疫球蛋白的关系[J]. 中华创伤杂志, 2013, 29(3): 236-240.

SU Hai,ZHANG Yi,SUN Xiao-chuan et al. Relationship between Mg²⁺ in serum and immune globulin in patients with severe traumatic brain injury[J]. CHINESE JOURNAL OF TRAUMA, 2013, 29(3): 236-240.

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http://www.zhcszz.com/CN/10.3760/cma.j.issn.1001-8050.2013.3.012 或 http://www.zhcszz.com/CN/Y2013/V29/I3/236

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