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| 轴向压应力与骨折愈合 |
| 重庆，第三军医大学附属新桥医院骨科，400037 |
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| Effects of axial compression force on fracture healing |
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| ［2］胥少汀, 葛宝丰, 徐印坎. 实用骨科学. 第2版. 北京：人民军医出版社, 2004:341-346.
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| ［9］Hazenberg JG, Hentunen TA, Heino TJ, et al. Microdamage detection and repair in bone: fracture mechanics, histology, cell biology. Technol Health Care, 2009, 17(1):67-75.
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| ［11］Long RK, Nishida S, Kubota T, et al. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J Bone Miner Res, 2011, 26(12):2948-2958.
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| ［12］Sun X, McLamore E, Kishore V, et al. Mechanical stretch induced calcium efflux from bone matrix stimulates osteoblasts. Bone, 2012, 50(3):581-591.
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| ［13］Barthelemi S, Robinet J, Garnotel R, et al. Mechanical forces-induced human osteoblasts differentiation involves MMP-2/MMP-13/MT1-MMP proteolytic cascade. J Cell Biochem, 2012, 113(3):760-772.
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| ［14］Lu C, Saless N, Hu D, et al. Mechanical stability affects angiogenesis during early fracture healing. J Orthop Trauma, 2011, 25(8):494-499.
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| ［17］Asada K, Obata K, Horiguchi K, et al. Age-related changes in afferent responses in sensory neurons to mechanical stimulation of osteoblasts in coculture system. Am J Physiol Cell Physiol, 2012, 302(5):C757-C765.
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| ［18］Hou WW, Zhu ZL, Zhou Y, et al. Involvement of Wnt activation in the micromechanical vibration-enhanced osteogenic response of osteoblasts. J Orthop Sci, 2011, 16(5):598-605.
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| ［19］Sarraf CE, Otto WR, Eastwood M. In vitro mesenchymal stem cell differentiation after mechanical stimulation. Cell Prolif, 2011, 44(1):99-108.
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| ［20］Liedert A, Wagner L, Seefried L, et al. Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells. Biochem Biophys Res Commun, 2010, 394(3):755-759.
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| ［21］Oreffo RO. Growth factors for skeletal reconstruction and fracture repair. Curr Opin Investig Drugs, 2004, 5(4):419-423.
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| ［24］Kim IS, Song YM, Hwang SJ. Osteogenic responses of human mesenchymal stromal cells to static stretch. J Dent Res, 2010, 89(10):1129-1134.
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| ［25］Meyer U, Meyer T, Schlegel W, et al. Tissue differentiation and cytokine synthesis during strain-related bone formation in distraction osteogenesis. Br J Oral Maxillofac Surg, 2001, 39(1):22-29.
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| ［26］Li J, Rose E, Frances D, et al. Effect of oscillating fluid flow stimulation on osteocyte mRNA expression. J Biomech, 2012, 45(2):247-251.
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| ［27］Koh A, Niikura T, Lee SY, et al. Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures. J Orthop Res, 2011, 29(12):1820-1826
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| ［28］Kesavan C, Wergedal JE, Lau KH, et al. Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading. Am J Physiol Endocrinol Metab, 2011, 301(6):E1191-E1197.
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| ［29］Peng Q, Wang Y, Qiu J, et al. A novel mechanical loading model for studying the distributions of strain and mechano-growth factor expression. Arch Biochem Biophys, 2011, 511(1-2):8-13.
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| ［30］Tokimasa C, Kawata T, Fujita T, et al. Effects of insulin-like growth factor-I on the expression of osteoclasts and osteoblasts in the nasopremaxillary suture under different masticatory loading conditions in growing mice. Arch Oral Biol, 2003, 48(1):31-38.
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| ［31］Olesen JL, Heinemeier KM, Haddad F, et al.Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon.J Appl Physiol, 2006, 101(1):183-188.
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| ［32］Tanaka M, Sakai A, Uchida S, et al. Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats. Bone, 2004, 34(6):940-948.
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| ［33］Sakuma Y, Li Z, Pilbeam CC, et al. Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cellls. Bone, 2004, 34(5):827-834.
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| ［34］Cameron KO, Lefker BA, Ke HZ, et al. Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett, 2009, 19(7):2075-2078.
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| ［35］Grimes R, Jepsen KJ, Fitch JL, et al. The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation. J Bone Miner Res, 2011, 26(11):2597-2609.
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| ［36］Cillo JE Jr, Gassner R, Koepsel RR, et al. Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: implication for distraction osteogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2000, 90(2):147-154.
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