Abstract:Objective To investigate correlation between change of renal artery diastolic function and subsequent heart failure following mechanical trauma. Methods Twenty-eight Wistar rats, of which four died from accidents, were divided randomly into sham group and trauma group (subgroups at 6 hours and 24 hours after trauma), with 8 rats per group. Models of mechanical trauma in rats were created by Noble-Collip drum. Maximum rate of left ventricular pressure rise (+dp/dtmax) and fall (-dp/dtmax) in rats were detected through isolated heart perfusion technique. Alteration of renal artery diastolic function was observed by isolated micro-vessel technique. Contents of angiotensin Ⅱ (Ang Ⅱ) in serum and myocardium tissue were tested by ELISA method. Results In vitro heart function in the group at 24 hours after trauma showed significant decrease and maximum endothelium-dependent diastolic response of renal artery vascular ring to acetylcholine(Ach) in the group at 6 hours after trauma showed obvious decrease, as compared with the sham group. Ang Ⅱ contents in serum and myocardium tissue in the groups at 6 and 24 hours after trauma were significantly higher than those in the sham group and appeared to be positively correlated. Meantime, Ang Ⅱ contents in myocardium tissue were negatively related to +dp/dtmax, but was positively correlated with-dp/dtmax. Conclusions Mechanical trauma may induce subsequent cardiac insufficiency by disturbing renal artery endothelium-dependent diastolic function. Moreover, excessive activation of Ang Ⅱ may play an important role in the entire process.
CAO Cheng-zhang,YAN Zi,WEN Yong-jin et al. Relationship between change of renal artery endotheliumdependent diastolic function and delayed heart failure after mechanical trauma[J]. CHINESE JOURNAL OF TRAUMA, 2013, 29(4): 348-352.
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