［1］Shlosberg D, Benifla M, Kaufer D, et al. Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat Rev Neurol, 2010, 6(7):393-403.
［2］Das M, Mohapatra S, Mohapatra SS. New perspectives on central and peripheral immune responses to acute traumatic brain injury. J Neuroinflammation, 2012, 9:236.
［3］Chodobski A, Zink BJ, Szmydynger-Chodobska J. Blood-brain barrier pathophysiology in traumatic brain injury. Transl Stroke Res, 2011, 2(4):492-516.
［4］Ehrlich P. Oxygen need by the organism: analytical study using color. Hirschwald, 1885, 8：167-167.
［5］Correale J, Villa A. Cellular elements of the blood-brain barrier. Neurochem Res, 2009, 34(12)：2067-2077.
［8］Begley DJ, Brightman MW. Structural and functional aspects of the blood-brain barrier. Prog Drug Res, 2003, 61:39-78.
［9］Wolburg H, Noell S, Mack A, et al. Brain endothelial cells and the glio–vascular complex. Cell Tissue Res, 2009, 335(1)：75-96.
［10］Wolburg H. The endothelial frontier∥Dermietzel R, Spray DC, Nedergaard M, eds. Blood-brain barriers: from ontogeny to artificial barriers. 1st et. Weinheim: Willey-VCH, 2006：77-107.
［11］Ng I,Yap E,Tan WL, et al. Blood-brain barrier disruption following traumatic brain injury: roles of tight junction proteins. Ann Acad Med Singapore,2003,32(5 Suppl):S63-S66.
［12］Kis B, Snipes JA, Deli MA, et al. Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins. Acta Neurochir Suppl, 2003, 86：565-568.
［13］Luissint AC, Artus C, Glacial F, et al. Tight junctions at the blood brain barrier:physiological architecture and disease-associated dysregulation. Fluids Barriers CNS,2012,9(1):23-23.
［14］Liu WY, Wang ZB, Zhang LC, et al. Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances. CNS NeurosciTher, 2012,18(8):609-615.
［15］Nag S, Kapadia A, Stewart DJ. Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury. Neuropathol Appl Neurobiol, 2011,37(1)：3-23.
［16］Parton RG, Richards AA. Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms. Traffic, 2003, 4(11)：724-738.
［17］Smyth A, O'Connor WT. Increased glutamate, aspartate and GABA levels following controlled cortical impact to the medial prefrontal cortex in the rat. Int J Neuropsychopharmacol, 2004, 7 Supp1：S474-S475.
［21］Morganti-Kossmann MC, Rancan M, Otto VI, et al. Role of cerebral inflammation after traumatic brain injury: a revisited concept. Shock, 2001, 16(3)：165-177.
［22］Bechmann I, Galea I, Perry VH. What is the blood-brain-barrier (not)? Trends Immunol, 2007, 28(1)：5-11.
［23］Bechmann I, Goldmann J, Kovac AD, et al. Circulating monocytic cells infiltrate layers of anterograde axonal degenera-tion where they transform into microglia. FASEB J, 2005, 19(6)：647-649.
［24］Fabriek BO, Van Haastert ES, Galea I, et al. CD163-positive perivascular mac-rophages in the human CNS express molecules for antigen recognition and presentation. Glia, 2005, 51(4)：297-305.
［25］Zenker D, Begley D, Bratzke H, et al. Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells. J Physiol, 2003, 551(Pt 3)：1023-1032.
［26］Correale J, Villa A. The neuroprotective role of inflammation in nervous system injuries. J Neurol, 2004, 251(11)：1304-1316.
［27］Del Zoppo GJ, Milner R, Mabuchi T, et al. Vascular matrix adhesion and the blood-brain barrier. Biochem Soc Trans, 2006, 34(Pt 6):1261-1266.
［28］Del Zoppo GJ, Milner R. Integrin-matrix interactions in the cerebral microvasculature. Arterioscler Thromb Vasc Biol, 2006, 26(9)：1966-1975.
［29］Rascher G, Fishmann A, Krger S, et al. Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of ten-ascin and agrin. Acta Neuropathol, 2002, 104(1)：85-91.
［30］Jian Liu K, Rosenberg GA. Matrix metalloproteinases and free radicals in cerebral ischemia. Free Radic Biol Med, 2005, 39(1)：71-80.
［31］Zlokovic BV. Remodeling after stroke. Nat Med, 2006, 12(4):390-391.
［32］Grossetete M, Phelps J, Arko L, et al. Elevation of matrix metalloproteinases 3 and 9 in cerebrospinal fluid and blood in patients with severe traumatic brain injury. Neurosurgery, 2009, 65(4)：702-708.
［33］Ding JY, Kreipke CW, Schafer P, et al. Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia inducible factor-1 alpha expression. Brain Res, 2009, 1268：125-134.
［34］Vajtr D, Benada O, Kukacka J, et al. Correlation of ultrastructural changes of endothelial cells and astrocytes occurring during blood brain barrier damage after traumatic brain injury with biochemical markers of BBB leakage and inflammatory response. Physiol Res, 2009, 58(2)：263-268.
［35］Rosenberg GA, Sullivan N, Esiri MM. White matter damage is associated with matrix metalloproteinases in vascular dementia. Stroke,2001,32(5):1162-1168.
［36］Buss A, Pech K, Kakulas BA, et al. Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury. BMC Neurol,2007,7:17.
［37］Yamaguchi M, Jadhav V, Obenaus A, et al. Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically- induced brain injury. Neurosurgery, 2007, 61(5)：1067-1075.
［38］Sifringer M, Stefovska V, Zentner I, et al. The role of matrix metalloproteinases in infant traumatic brain injury. Neurobiol Dis, 2007, 25(3)：526-535.
［39］Truettner JS, Alonso OF, Dalton Dietrich W. Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats. J Cereb Blood Flow Metab, 2005, 25(11)：1505-1516.
［40］Wang J, Tsirka SE. Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage. Brain, 2005, 128(Pt7)：1622-1633.
［41］Rosell A, Lo EH. Multiphasic roles for matrix metalloproteinases after stroke. Curr Opin Pharmacol, 2008, 8(1)：82-89.
［42］Shigemori Y, Katayama Y, Mori T, et al. Matrix metalloproteinase- 9 is associated with blood-brain barrier opening and brain edema formation after cortical contusion in rats. Acta Neurochir Suppl, 2006, 96(1)：130-133.
［43］Abbott NJ, Patabendige AA, Dolman DE, et al. Structure and function of the blood-brain barrier. Neurobiol Dis, 2010, 37(1)：13-25.
